The Douglass Lab combines the tools of organic chemistry, biochemistry and computational biology to overcome the urgent problem of multi-drug resistance (MDR) in cancer.  Typically, MDR is caused by ~30 drug efflux and metabolism enzymes which can create 30 different types of “armor” for late stage cancers.   Our Organic Chemistry program seeks to modify current chemotherapies to become “armor piercing”, our Biochemistry program seeks to characterize each “armor” substrate specificity (kcat/Km) and our Data-Science programs focuses on building clinical diagnostics to match drugs to individual patients.