Walter K. Schmidt
Professor, Franklin College of Arts and Sciences, Department of Biochemistry and Molecular Biology
Ras oncoprotein activity is strongly influenced by post-translational modifications that occur at the COOH-terminus: isoprenylation, palmitoylation, proteolysis, and carboxylmethylation. Our studies are focused on the enzymes that direct these modifications and range from investigations of enzyme specificity to inhibitor development.