Associate Vice President for Research • Director, Office of Internal Grants and Awards
- The Hooks lab studies the signaling pathways that promote cancer cell growth and survival. Specifically, we investigate receptor signaling pathways in both tumor cells and the neighboring immune cells that produce inflammatory mediators that create a tumor-supportive microenvironment. Active projects are focused on the role of inflammatory signaling in tumor associated macrophages in ovarian cancer progression and chemoresistance. We are exploring a novel mechanism by which G-proteins regulators control expression of COX-2 and production of prostaglandins using a combination of cell-line and animal models.